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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

While generally considered safe, use during pregnancy and breastfeeding should be discussed with a doctor

Bibcode:2005PNAS..10211278M

Administration Tips for Weekly Dosing When giving Vitamin B12 injections weekly, proper technique is vital

Given that implanted chondrocytes are major cells that account for creating new tissues, their quality may directly affect the phenotype and function of regenerated cartilage